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Respiratory, thoracic and mediastinal Conditions: dyspnea, hiccups Skin and subcutaneous tissue Problems: rash

Overdose If someone has overdosed and has significant indicators which include passing out or trouble respiratory, provide them with naloxone if offered, then call 911.

Oxycodone hydrochloride tablets are an immediate-launch oral formulation of oxycodone hydrochloride indicated for that management of average to severe agony wherever the use of an opioid analgesic is appropriate.

Evaluate sufferers for indications of urinary retention or lowered gastric motility when OXYCONTIN is made use of concomitantly with anticholinergic drugs.

Clients must be suggested that if they have been obtaining remedy with oxycodone hydrochloride tablets for more than a few months and cessation of therapy is indicated, it could be ideal to taper the oxycodone hydrochloride tablets dose, as an alternative to abruptly discontinue it, on account of the risk of precipitating withdrawal indicators.

To minimize the prospect of choking or possessing hassle swallowing the tablet, just take just one a tablet at a time If the dose is for more than one tablet. Do not pre-soak, lick, or soaked the tablet right before placing it within your mouth. Make sure to drink sufficient drinking water with each tablet to swallow it absolutely.

Oxycodone and its metabolites are excreted mainly through the kidney. The quantities calculated inside the urine are described as follows: free and conjugated oxycodone 8.

Keep away from more info ingesting grapefruit or drinking grapefruit juice while applying this medication Except if your physician or pharmacist suggests you could possibly do so properly. Grapefruit can raise the prospect of Unintended effects with this medicine. Check with your medical doctor or pharmacist For additional check here specifics.

Usage of opioids for an extended period of time could trigger diminished fertility in women and males of reproductive potential. It's not recognised no matter if check here these effects on fertility are reversible [see ADVERSE REACTIONS, CLINICAL PHARMACOLOGY and Nonclinical Toxicology].

Scenarios of androgen deficiency have transpired with utilization of opioids for an extended read more period of time [see Scientific PHARMACOLOGY].

Oxycodone hydrochloride was genotoxic within an in vitro mouse lymphoma assay within the presence of metabolic activation. There was no evidence of genotoxic probable within an in vitro bacterial reverse mutation assay (Salmonella typhimurium and Escherichia coli) or in an assay for chromosomal aberrations (in vivo mouse bone marrow micronucleus assay).

The oxycodone in OXYCONTIN may well raise the frequency of seizures in patients with seizure Diseases and could raise the danger of seizures developing in other medical configurations linked with seizures.

On account of the assorted elements causing incomplete cross tolerance between opioids, and/or interpatient dissimilarities in opioid-induced read more analgesia, an OME reduction ought to be employed when transitioning from one opioid to a different.

Infants born to mothers physically dependent on opioids will likely be physically dependent and will exhibit respiratory complications and withdrawal indicators [see Use In Precise Populations].